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Global X S&P Biotech ETF

About this ETF

Invests in an equally-weighted portfolio of small, mid and large-cap companies focused on genetic research, immunotherapy and vaccine development, rebalanced quarterly.

IssuerGlobal X
Management fee (MER)0.45% p.a.
Inception date8 Nov 2018
BenchmarkS&P Biotechnology Select Industry Index

Scout Score

57/100
Ranked #16 of 50 in Thematic

An independent score calculated by ETF Scout across 7 real-data factors (cost, diversification, tracking, liquidity, fund strength, performance, income), ranked against other funds in the same category.

Cost78
Diversification100
Tracking42
Liquidity22
Fund Strength47
Performance—
Income19

Strengths

  • Well diversified — top holdings are 14.5% of the fund, less concentrated than 100% of Thematic peers.
  • Low fee — 0.45% p.a., cheaper than 78% of Thematic funds.

Weaknesses

  • Below-average yield — 0.03%, lower than 81% of Thematic peers.
  • Lower liquidity — 0.24% bid/ask spread, wider than 78% of Thematic peers.

Performance (as of 5 Nov 2026)

Total returns, net of fees. Periods longer than 1 year are annualised.

1 Month-4.76%
3 Months-1.65%
YTD+16.47%
1 Year+26.94%
3 Years (p.a.)+24.40%
5 Years (p.a.)+3.63%

Price history

Cumulative return over the selected period, indexed to 0% at the start of the range.

-55%-31%-6%+19%+44%2021-112023-022024-052025-082026-11

Top holdings (as of 13 Aug 2026)

The fund's largest individual holdings, ranked by portfolio weight.

  1. 1.Twist Bioscience1.73%
  2. 2.Oruka Therapeuti1.57%
  3. 3.Apogee Therapeut1.53%
  4. 4.Praxis Precision1.51%
  5. 5.Dianthus Therape1.38%
  6. 6.Natera Inc1.37%
  7. 7.Kymera Therapeut1.37%
  8. 8.Insmed Inc1.35%
  9. 9.Halozyme Therape1.35%
  10. 10.Protagonist Ther1.35%